You might think that neuroscientists already have enough brains, but apparently not. Over 100 neuroscientists attending the recent annual meeting of the Society for Neuroscience (SFN), took part in an annotation challenge: modifying scientific papers to add simple references that automatically generate and attach Hypothesis annotations, filled with key related information. To sweeten the pot, our friends at Gigascience gave researchers who annotated their own papers their very own brain hats. But handing out brains is not just a conference gimmick. Thanks to our colleagues at the Neuroscience Information Framework (NIF), Hypothesis was once again featured at SFN, the largest gathering of neuroscientists in the world, attended by well over 30,000 people in San Diego Nov 12-16, 2016. The annotation challenge at SFN was a demonstration of a much larger collaboration with NIF: to increase rigor and reproducibility in neuroscience by using the NIF’s new SciBot service to annotate publications automatically with links to related materials and tools that researchers use in scientific studies.